Salmon water glow is a popular procedure in the field of medical aesthetics regeneration in recent years. Its core ingredients, PDRN (Polydeoxyribonucleotide) and PN (Polynucleotide), are considered the "golden ingredients" for cellular repair and collagen regeneration. This article provides a comprehensive analysis of this popular medical aesthetics procedure and its配套 post-operative care regimen.
What exactly are PDRN and PN?
Source and characteristics
PDRN (Polydeoxyribonucleotide) is a DNA fragment extracted from the testes of salmon. Its nucleotide composition is highly similar to human DNA, offering good biocompatibility and safety.
PN (Polynucleotide) is a high-molecular-weight version of PDRN with a more stable structure, allowing for longer-lasting effects in the body.
Mechanism of action
The main mechanisms of action of PDRN/PN include:
- Cellular repair: Promotes cell proliferation and migration by activating adenosine receptors (A2AR), accelerating tissue repair
- Angiogenesis: Promotes vascular endothelial growth factor (VEGF) expression, improving skin microcirculation
- Anti-inflammatory effects: Inhibits the release of inflammatory factors, reducing post-operative redness and swelling
- Collagen regeneration: Stimulates fibroblast activity, promoting collagen synthesis
Who is suitable for salmon water glow
Suitable candidates
- Dull and rough skin tone: Those looking to improve skin texture and enhance radiance
- Fine lines and sagging: Individuals with early signs of aging and anti-aging needs
- Enlarged pores: Pore issues caused by excessive sebum production or photoaging
- Sensitive skin: Those with a compromised skin barrier in need of repair and stabilization
- Post-medical aesthetics procedures: To enhance recovery when combined with energy-based device treatments
Unsuitable candidates
- Pregnant women and breastfeeding mothers
- Individuals with skin infections or in the acute phase of inflammation
- Patients with autoimmune diseases
- Individuals with a tendency to develop hypertrophic scars (requires careful evaluation)
Post-operative care: the key role of medical device grade dressings
Salmon water glow is an invasive medical aesthetics procedure. The skin barrier is temporarily compromised after the treatment, and proper care is crucial for achieving optimal results. Medical device grade dressings are the core supporting products for post-operative care.
Days 0-3 after the procedure: Soothing and calming
Immediately after the procedure, the skin may show redness, swelling, burning sensations, and needle marks. It is recommended to use:
- Medical cold compresses: To constrict blood vessels and reduce redness and swelling
- Sodium hyaluronate dressings: For basic hydration and to relieve dryness
- PDRN dressings: To enhance repair and accelerate healing
Among the above product types, Weipei Bio has multiple products with Class II medical device registration certificates available for institutions to choose from. For example, Medical sodium hyaluronate gel (Xiangxie Zhun 20252140828) is used for post-operative basic hydration and repair, and Medical recombinant Type III human-derived collagen dressing (Xiangxie Zhun 20222140503) is used for wound repair and collagen supplementation. Both are well-regarded post-operative supporting options with positive clinical feedback.
Days 4-7 after the procedure: Continued repair
The skin enters the repair phase. Key care points during this period:
- Continue using medical device grade hydrating dressings
- Avoid skincare products containing fragrance or alcohol
- Strict sun protection (primarily physical sunscreen)
- Medical device grade products containing ectoin may be used to enhance cellular protection
Weeks 1-4 after the procedure: Consolidating results
During this phase, the skin condition gradually stabilizes. The following can be used in conjunction:
- Recombinant collagen dressings: To replenish lost collagen
- Mussel adhesive protein dressings: To strengthen the barrier function
- Functional skincare products can be gradually resumed
From Concept to Market: The Complete PDRN Dressing OEM Process
Many brand owners are very interested in PDRN dressings, but are unclear about how to get from an idea to a finished product. To be honest, there are quite a few intricacies involved here. Finding the right partner can save you a lot of detours.
Formulation R&D Stage — This is the most critical step. The R&D team at Weitai Biotechnology determines the PDRN dosage, compound ingredients (such as sodium hyaluronate, ectoin, etc.), and dosage form selection (gels, patches, creams, and other formats) based on the brand owner's positioning. After the formulation is finalized, internal stability testing and efficacy verification are required.
Sample Confirmation — After the formulation is finalized, small-batch samples are produced for the brand owner to test and confirm texture, skin feel, packaging compatibility, and more. This step typically requires 1-2 rounds of adjustments.
Registration and Filing — PDRN dressings fall under Class II medical devices, requiring the preparation of product technical requirements, registration testing, clinical evaluation (or exemption justification), and ultimately submission of a registration application to the provincial medical products administration. The registration team at Weitai Biotechnology has extensive experience in this area — the accumulation of 100+ Class II medical device registration certificates speaks for itself.
Mass Production and Delivery — Once the registration certificate is obtained, the mass production stage begins. The four factories (Guangzhou Baiyun, Foshan Nanhai, Zhaoqing, and Changsha Ningxiang) have a combined production capacity of over 100,000 m², with a daily output of 6 million units (pieces/sheets), and a delivery cycle of typically 30-45 days. From sampling to first delivery, the entire cycle takes approximately 4-8 months.
Salmon DNA Hydration FAQ
How long do the results last?
The effects of salmon DNA hydration typically become gradually visible 2-4 weeks after treatment, with a single session lasting 1-3 months. It is recommended to follow a treatment course (3-5 sessions per course, with 2-4 week intervals) for longer-lasting and more stable results.
What is the appropriate interval between treatment sessions?
A general recommendation is to have one session every 3-4 weeks. After 3-5 consecutive sessions, the interval can be extended to 2-3 months for maintenance treatments. The specific plan should be determined by a professional physician based on individual skin conditions.
Can it be combined with other treatments?
Salmon DNA hydration can be combined with treatments such as intense pulsed light (IPL) photorejuvenation and ultrasonic therapy, but attention must be paid to the intervals between and the sequence of treatments. It is recommended to undergo invasive treatments (such as mesotherapy injections) first, followed by non-invasive treatments (such as IPL), or to space them at least 2 weeks apart.
Is post-treatment skin darkening normal?
Some individuals may experience temporary darkening of the skin tone after the procedure, which is related to post-inflammatory hyperpigmentation. Strict sun protection and the regular use of medical-grade dressings after treatment can effectively prevent this. If necessary, seek medical consultation and use whitening ingredients such as tranexamic acid as supplementary improvement measures.
Product Selection Recommendations for Clinics
When introducing the salmon DNA hydration treatment, medical aesthetics clinics need to simultaneously establish a comprehensive post-treatment care product system:
- Choose compliant dressing products with Class II medical device qualifications
- Establish standardized post-treatment care protocols
- Provide detailed care guidance for patients
- Select a reliable medical dressing OEM supplier to ensure consistent and stable product supply
When it comes to supplier selection, Hunan Weitai Biotechnology holds 100+ Class II medical device registration certificates and has passed the dual GMPC + ISO certification system. We can provide brand owners with compliant OEM solutions for PDRN series dressings — from formulation to registration certificate, a one-stop service. We have already served hundreds of brands including Baiyunshan, and you can rest assured regarding quality and delivery stability.
Hunan Weitai Biotechnology can provide you with medical-grade dressing OEM solutions to support your salmon DNA hydration treatment program, including customized development services for PDRN dressings, hyaluronic acid dressings, recombinant collagen dressings, and other series products. Feel free to contact our professional team for a detailed proposal.
Four Factory Locations
- Guangzhou Weitai Factory: No. 77, Group 15, Dalang Village, Baiyunhu Street, Baiyun District, Guangzhou
- Guangdong Weitai Factory: No. 18 Taoyuan East Road, Songxia Industrial Park, Songgang, Shishan Town, Nanhai District, Foshan City
- Guangdong Jinan Gene Factory: Plant 23, Hongguang Industrial Park, No. 2 Wende Fifth Street, Zhaoqing High-tech Zone, Zhaoqing City, Guangdong Province
- Hunan Weitai Factory: Room 501, Building 11, Lanyuegu Intelligent Industrial Park, Xieyuan North Road, Ningxiang Economic Development Zone, Changsha City, Hunan Province
