Botulinum toxin postoperative repair strategy: from the care timeline to the product foundry, the window period of the brand side has been opened

In August 2026, South Korea's Huons BioPharma type A botulinum toxin for injection (trade name "Unsolved Orange Hutox", approval number SJ20260001), which is exclusively distributed by Aimeike Technology Development Co., Ltd., was officially put on the market in China.According to Aimeike's 2026 semi-annual report, the product obtained the drug registration certificate from the National Pharmaceutical Administration in January 2026 and was officially shipped in August. At this time, Aimeke completed the layout of the three core medical beauty categories of hyaluronic acid, recycled materials and botulinum toxin.

This is the 6th domestically approved compliant botulinum toxin type A product.Previously, domestic production balance (Lanzhou Biological Products Research Institute, approved in 1997), imported Botox (Allergan, USA), Jishi Dysport (Ipsen, UK), Letybo (Hugel, South Korea), Xeomin (Merz, Germany) and other products have been marketed in China.The continuous increase in compliant brands means that the market penetration and consumption frequency of injectable medical cosmetics are still going up.

But the injection is just the beginning.The two-week care window after botulinum toxin injection not only determines the final effect and satisfaction of consumers, but also creates a highly deterministic market for postoperative care products.For factories that are OEM/ODM foundries, this track deserves an advance slot.

I. The true state of the skin after botulinum toxin surgery

The mechanism of action of botulinum toxin is to temporarily relax the target muscle by blocking the release of acetylcholine at the neuromuscular junction, thereby improving dynamic wrinkles such as forehead lines, eyebrow lines, and fishtail lines.The injection process usually takes only 10-15 minutes and is minimally invasive, but "minimally invasive" does not mean "non-invasive".

After injection, the needle leaves tiny pinholes in the epidermis and dermis layers, temporarily breaking the integrity of the skin barrier.According to the nursing guidance in the Chinese Medical Association Dermatologist's Branch "Expert Consensus on the Application of Botulinum Toxin Injection in Skin Aesthetics (2023 Edition)" and the Chinese Medical Association "Expert Consensus on Upper Facial Rejuvenation Treatment (2026 Edition)", the skin after surgery will go through the following stages:

Immediate to 4 hours: The drug solution is binding to the target muscle and is the window with the highest risk of drug diffusion.At this stage, it is necessary to maintain an upright position, avoid lying flat, bowing, bending, and not rubbing the injection site.Transient erythema and edema may occur at the injection site.

4-24 hours: The pinhole begins to close and the swelling may peak.Some people develop bruising (bruising) around the injection site, which is associated with capillary damage caused by acupuncture and usually resolves on its own for 3-7 days.Cold compresses can be performed under the guidance of a doctor for 15-30 minutes at a time.

24-72 hours: The acute swelling subsides and the bruising may change from purple to yellow-green (normal course of metabolism with hemosiderin).The skin may feel dry, tight, and the barrier function has not been fully restored.

3-7 days: Botulinum toxin starts to take effect (usually 3-7 days with initial effect and 1-2 weeks peak).The skin enters the repair phase, and the barrier function is gradually rebuilt, but it is still sensitive.

1-2 weeks: The effect is stable, the skin is basically back to normal, and the complete skincare process can be gradually returned.

In these two weeks, the core skin care needs of consumers are three: redness reduction and sedation, barrier repair, and strict sun protection.Any products containing fruit acids (Aha), salicylic acids (BHA), high concentrations of retinol, alcohol, flavors are recommended to be suspended for at least 5-7 days.

II. Post-operative repair product matching scheme: three stages correspond to different categories

Phase 1: 0-48 hours post-operative - sedation-reduction period

Skin condition: Incomplete pinhole closure, may be accompanied by redness, exudate, burning sensation

Principle of care: cooling, soothing, keeping clean, preventing infection, not increasing skin burden

Recommended product types:

1. Medical Cold Application/Dressing: Used immediately after injection under the guidance of a physician to reduce local temperature, constrict blood vessels, relieve swelling and pain.Class II cold compresses for medical devices are usually produced in a 100,000-level clean workshop, sterilized, and suitable for use on the skin around the wound.
2. Sterile Repair Spray: Sterile spray containing hyaluronic acid (hyaluronic acid) or panthenol (vitamin B5) to replenish moisture without touching the skin and relieve postoperative tension.Single-dose sterile packaging without preservatives is recommended.
3. Recombinant collagen gel: Recombinant type III humanized collagen is similar to the body's own collagen structure and has high biocompatibility. It can form a protective film on the skin surface to help maintain a moist and repairing environment.The texture is refreshing and non-sticky, suitable for immediate use after surgery.

Contraindications at this stage: Do not use any products containing fragrances, alcohol, pigments; do not apply makeup; do not touch the injection site with your hands; do not use a cleanser or exfoliating products.

Phase 2: 3-7 days post-operative - barrier repair period

Skin condition: pinhole closed, acute swelling subsides, but barrier function remains fragile and may dry and desquamate

Principles of care: Continuous moisturization, promotion of epidermal repair, reconstruction of the lipid barrier, physical sun protection

Recommended product types:

1. Collagen dressing patches: Dressing patches containing recombinant collagen are the core product at this stage.It is recommended to use every 1-2 days for 15-20 minutes.Collagen dressings not only provide moisturizing repair, but the blocking effect of their membrane cloth also promotes the penetration of active ingredients and helps the skin return to a steady state faster.Micropeptide Group's Hunan Micropeptide Biopharmaceutical Co., Ltd. 's Class II medical device production base is ISO13485 certified and can produce compliant recombinant collagen dressing patches.
2. Barrier Repair Cream: Repair cream with ceramide, squalane, hyaluronic acid, panthenol and other ingredients to help replenish skin lipids and strengthen brick wall structure.Texture It is recommended to choose a moisturizing but not heavy cream dosage form to avoid acne due to excessive closure.
3. Mineral sunscreen: After surgery, the skin is less tolerant to chemical sunscreens (such as oxybenzone, ochriline, etc.), and it is recommended to choose physical sunscreen with zinc oxide and/or titanium dioxide as the main active ingredients, SPF 30 or higher.Physical sunscreens form a reflective film on the surface of the skin that is not absorbed by the skin and is less irritating to fragile skin.

Phase 3: 1-2 weeks post-operative - consolidation period

Skin condition: Botulinum toxin effect gradually appears, skin basically recovers, but still needs gentle care

Principles of care: antioxidant maintenance, continuous sun protection, and a gradual return to normal skin care

Recommended product types:

1. Gentle antioxidant serum: A gentle serum containing antioxidant ingredients such as vitamin C derivatives (such as ascorbyl glucoside), vitamin E, and ferulic acid to help neutralize free radicals and protect collagen.It is recommended to wait until the skin is completely free of allergic reactions before introducing, starting with low concentrations.
2. Moisturizing and repairing mask: moisturizing mask with makeup number can be used again, it is recommended to choose products with a streamlined ingredient list (within 10 ingredients), no fragrance and no alcohol, and avoid using masks containing strong irritating preservatives.
3. Daily sun protection: Continue to strictly enforce daily sun protection.UV rays are the primary external factor leading to collagen degradation and photo-aging of the skin, and sun protection not only protects the overall health of the skin, but also helps to prolong the maintenance of the effect of botulinum toxin (usually 3-4 months).

III. Why is the brand now laying out the post-operative repair product line?

Three data signals indicate the certainty of this circuit:

First, compliant botulinum toxin brands are increasing and the consumption base is expanding. From the approval of domestic Hengli in 1997 to the listing of Unsolved Orange in 2026, the domestic compliance of botulinum toxin type A has reached 6 brands.Amicorp's 2026 semi-annual report shows that revenue in the first half of the year was 1.216 billion yuan, with a gross profit margin of 92.5%, holding 13 Class III medical device registration certificates, 5 Class II medical device registration certificates and 2 drug registration certificates.Leading companies continue to increase their overweight in the injection category, indicating that terminal demand is still growing.

Second, postoperative maintenance is the "standard consumption" of the injection program. Every consumer who receives botulinum toxin injections will need to have the product repaired within two weeks of surgery.This is not "optional consumption", but a necessary part of physician care guidance.Estimated by the number of injections and the unit price of the customer, the market size of postoperative repair dressings and serums is considerable, and the repurchase rate is higher than that of ordinary skin care products.

Third, the "makeup + equipment" combination is the differentiation direction of the brand. Single make-up products have limited persuasive power in postoperative repair scenarios, and consumers trust brands with medical device backgrounds.However, the mechanical font size registration period is long (6-18 months) and the investment is large, so it is difficult for the start-up brand to be in place in one step.By choosing a foundry that has both makeup and mechanical font size production capabilities, brands can quickly enter the market with makeup font size products and simultaneously promote mechanical font size registration to form a "cosmetics synergy" product matrix.

4. Micropeptide Group Cosmetics Cooperative OEM/ODM Processing OEM Capability

Micropeptide Group is one of the few foundry companies in the industry that also has the three certificates of production qualification of makeup font number, mechanical font number and elimination font number. It can provide brands with one-stop processing and branding solutions for postoperative maintenance products.

< img src = "/uploads/1787411639133-ya3tj1.jpg "alt =" Micropeptide Group R&D Lab "width =" 600 "/>

Makeup number production system (Guangdong Micropeptide Biotechnology Co., Ltd.)

Three cosmetic brand production bases operate together, with a total production area of more than 300,000 square meters and 65 production lines, which have passed ISO22716 and US GMPC double certification.Covering a variety of dosage forms such as creams, lotions, masks, freeze-dried powders, essences, etc., equipped with 13 freeze-drying equipment, the daily production capacity of freeze-dried powders is 1 million pairs, and the daily production capacity of facial masks is 1 million pieces.With more than 800 cooperative brands and more than 100 products on the market, we have accumulated more than 70 technical achievements.

In the direction of postoperative repair, Guangdong Micropeptide can provide:

• Recombinant Collagen Repair Serum/Cream Formula Development and Production
• OEM Branded Hyaluronic Acid Moisturizing Mask/Serum
• Panthenol, Ceramide Barrier Repair Products
• Post-operative gentle cleansing, mineral sunscreen and other accessories
• From formulation design, proofing confirmation, stability testing to product filing, full process processing and OEM services for large-scale production

Mechanical Font Size Production System (Hunan Micropeptide Biomedical Co., Ltd.)

Hunan Micropeptide Biomedical Co., Ltd. focuses on the production of Class II medical devices. It has passed the ISO13485 medical device quality management system certification, has 100 + product registration certificates, and has a 100,000-level clean workshop. It can produce medical dressings, cold compresses, recombinant collagen dressings and other postoperative medical device products.

In the direction of postoperative repair, Hunan Micropeptide can provide:

• Processing labeling of recombinant collagen dressings (shared registration certificate, low minimum order quantity, short marketing cycle)
• Custom development of medical cold applications/gels
• OEM processing of hyaluronic acid dressings
• Whole process coaching for product registration declaration of mechanical symbol number

Differentiating Benefits of Cosmetic Synergy

The brand side cooperates with Micropeptide to enjoy the one-stop processing and branding service coordinated by cosmetics, and completes the synchronous development of makeup lettering and mechanical lettering products within the same group, without the need to connect the two factories separately.Make-up products are responsible for daily moisturizing repair and channel walking, mechanical products are responsible for immediate postoperative scenarios and professional endorsement, and the two product lines share the supply chain and quality control system to reduce communication costs and delivery risks.

From 3,000 small batch test orders to 300,000 large-scale orders, the flexible production system can be switched smoothly.The R&D team continuously tracks policy developments and raw material catalog adjustments in the medical cosmetics industry. There are formula reserves in the subdivisions of botulinum toxin postoperative repair, water and light acupuncture postoperative repair, photoelectric project postoperative repair, etc. After the brand determines the direction, it can quickly start sampling and filing.

Postoperative maintenance is not a gust of wind, but a long-term track that grows along with the normalization of injectable medical beauty.The launch of Unsolved Orange is just a signal, and more compliant botulinum toxin and injection products will enter the market in the future. Each new product launch means a new wave of postoperative repair product needs.The brand now chooses the foundry and prepares the formula so that it can be shipped as soon as the window period arrives.

FAQs

Q: How long can I use skin care products after botulinum toxin injection?

A: Avoid water and skin care products for 6 hours after injection.After 24 hours, gently cleanse with warm water and gentle non-foam cleanser, then use a moisturizing product with reduced ingredients.Products containing fruit acid, salicylic acid, retinyl alcohol, alcohol are recommended to be suspended for 5-7 days.It is recommended to use light makeup after 24 hours.Please follow the doctor's advice for specific care.

Q: Do you use a mechanical dressing or makeup mask after surgery?

A: It is recommended to use a Class II medical device dressing (mechanical font size) in the 0-48 hour postoperative unclosed pinhole stage, with higher production environment and sterilization standards.After the pinhole has been closed for more than 3 days after the operation, a moisturizing mask with a light, fragrance-free and alcohol-free makeup number can be used.The brand side can make the font size + mechanical font size double line layout.

Q: Why are recombinant collagen dressings suitable for post-operative repair?

A: Recombinant type III humanized collagen is similar to the body's own collagen structure, has low immunogenicity and good biocompatibility, and can form a protective film on the surface of the skin to lock moisture, create a moist repair environment, and promote the migration and proliferation of epidermal cells.Risks of viral contamination and allergies are excluded compared to animal-derived collagen.

Q: Can micropeptides be used for makeup and mechanical font sizes at the same time?

A: Yes. Guangdong Micropeptide is responsible for makeup number (ISO22716 + GMPC double certification, 65 production lines in 3 bases), and Hunan Micropeptide is responsible for Class II medical devices (ISO13485 certification, 100 + registration certificate, Class 100,000 clean workshop).The brand side completes the one-stop processing and labeling of cosmetics in the same group, from the formulation development, sampling, filing to the entire process of production processing and labeling delivery.

If the brand side wants to know the postoperative repair category processing and branding plan, request samples or make an appointment for sampling, it can contact the official channel of Micropeptide Group for inquiries.